Paper Details Design of ADAPTABLE, First Pragmatic Trial to Use PCORnet®
A paper recently published in JAMA Cardiology details the design of ADAPTABLE, a DCRI-led pragmatic clinical trial that uses many novel elements to efficiently answer a question that has substantial impacts on public health. ADAPTABLE seeks to determine the optimal dose of aspirin for patients with heart disease. Although aspirin has been used as a secondary prevention method for nearly three decades, the question of whether low-dose or high-dose aspirin is more beneficial remains unanswered.
Preventing Alzheimer’s Disease? Taking the First Step Through the TOMMORROW Trial
The study sought to simultaneously test a method for identifying individuals at high risk for Alzheimer’s disease while testing the efficacy of a potential treatment aimed at targets affecting cell
Patient-Reported Health Data in Pragmatic Trials: Helpful, But Not Without Limitations
A report from an NIH Health Care Systems Research Collaboratory roundtable recently published in
12-month SECURE-PCI Results add Context to Original Findings
Although initial results from SECURE-PCI suggested that patients treated with periprocedural loading doses of atorvastatin and undergoing percutaneous coronary intervention (PCI) experienced a reduced risk of major adverse cardiovascular events (MACE), extended follow-up showed no significant difference. The 12-month results, which were recently published in JAMA, expand upon the initial study, which followed patients for 30 days.
New DCRI Registry Could Provide Path for Pediatric Migraine Drug Development
A recently published paper details the development and design of the FDA-funded Pediatric Migraine Registry, which has enrolled around 200 patients between the ages of 4 and 17.
Interventional Cardiologists Must Stay Up-to-date on Training to Avoid ‘Proficiency Divide’
The DCRI’s Sunil Rao, MD, writes that to deliver high quality care, interventional cardiologists must constantly evaluate their practice and learn new techniques and skills.
DCRI and Digital Solutions: A New World of Evidence Generation
From thought leadership on a national stage to driving adoption for digital health technologies, the DCRI is leading the way in the digital therapeutic space.
Special Considerations for Resuscitation of Older Patients
Resuscitation after out-of-hospital cardiac arrest should not be administered using a one-size-fits-all approach, especially when treating older patients, according to an editorial in
UPDATE: DCRI Researchers Discuss Recruitment Challenges for Coronavirus Trials
The DCRI’s Michael Pencina, PhD, and Sheng Luo, PhD, discussed the design of two new Phase 3 clinical trials testing a potential treatment for coronavirus.
System-Wide Change Needed to Conduct More Randomized Clinical Trials at Lower Cost
A focus on building a nationwide system of real-world data could provide the opportunity for more randomized clinical trials to generate needed evidence to inform health care decisions.