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Adrian F. Hernandez, MD, MHS
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Adrian F. Hernandez MD, MHS

Director, Health Services and Outcomes Research

Faculty Associate Director

Associate Professor of Medicine, Cardiology, Duke University School of Medicine


Dr. Hernandez is a cardiologist with extensive experience in clinical research ranging from clinical trials to outcomes and health services research. He is the Faculty Associate Director of the Duke Clinical Research Institute (DCRI) and Director of the Health Services and Outcomes Research at the DCRI. He has led several research grants funded to address issues in clinical care, health policy, quality of care, and outcomes. He is the principal investigator (PI) of multiple large studies including the NHLBI's Heart Failure Research Network, the PCORI-funded study, PROSPER, on comparative effectiveness in stroke and the AHA’s Get With the Guidelines Registry. He is also the coordinating center PI for PCORI’s PCORNet and the NIH’s Health Systems Research Collaboratory, both of which aim to transform clinical research using electronic health records and health system data. He is the PI of the coordinating center for several large clinical trials including ASCEND-HF (nesiritide/heart failure), EXSCEL (exenatide/diabetes) and HARMONY-Outcomes (albiglutide/diabetes).

Dr. Hernandez has more than 300 published articles in high-tier journals on cardiovascular outcomes including the New England Journal of Medicine, Journal of the American Medical Association, and Lancet. He serves on the leadership of several national committees such as AHA’s Scientific Sessions, AHA’s Heart Failure Committee, ACCF Task Force on Clinical Expert Consensus Committee, and HFSA Guidelines Committee. He has been recognized for his research through numerous awards and was elected to the American Society of Clinical Investigation in 2012. He has mentored over 25 students, residents, fellows and faculty and has and a recipient of the the DCRI's Robert M. Califf Mentorship Award.