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About Us

As part of the Duke University School of Medicine, the Duke Clinical Research Institute is known for conducting groundbreaking multinational clinical trials, managing major national patient registries, and performing landmark outcomes research.

DCRI research spans multiple disciplines, from pediatrics to geriatrics, primary care to subspecialty medicine, and genomics to proteomics. The DCRI also is home to the Duke Databank for Cardiovascular Diseases, the largest and oldest institutional cardiovascular database in the world, which continues to inform clinical decision-making 40 years after its founding.

 


 

Our mission is to develop and share knowledge that improves the care of patients around the world through innovative clinical research.

 


 

Our ARO Model

What sets us apart?

As the world’s largest academic research organization (ARO), we combine the clinical expertise and academic leadership of a premier teaching hospital with the full-service operational capabilities of a major contract research organization.

Our leaders are some of the world's foremost authorities on the science, study, and application of clinical research, making them uniquely positioned to understand the operational, financial, and regulatory implications of numerous project designs, to the great benefit of our clients.

Building on more than 40 years of experience in innovative approaches to analyze the impact of various therapies on patient outcomes, the DCRI offers full clinical trial services as well as substantial resources dedicated to outcomes research and assessments, clinical database design and management, and medical education.

The ARO model of doing business

The DCRI supports the research interests of Duke faculty across an almost limitless array of therapeutic areas.

Our faculty are all practicing physicians in these specialties, applying cutting-edge research in their own patient care. Their informed input on study design and interpretation creates more efficient, practical, and hard-hitting research.

With more than 1200 faculty and staff, the DCRI is capable of conducting any clinical research project, from the smallest pilot study to truly global megatrials, as well as medical device trials to outcomes and quality of life analyses. Our experience stretches from phase I to phase IV and beyond, encompassing postapproval analyses and health economics.

Sharing knowledge to improve health is our priority.

The goal of all our research is to achieve the DCRI’s mission to improve the practice of medicine.

Our faculty focus strongly on disseminating research results, publishing more than 600 articles per year in peer-reviewed journals. Their effects on patient care and the state of medicine are felt around the world.

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Fast Facts
  • Conducted studies at more than 37,000 sites in 65 countries
  • Employs more than 1,200 employees, including 220 faculty
  • Manages numerous national patient registries
  • Enrolled more than 1.2 million patients in DCRI studies
  • Published more than 8,300 papers in peer-reviewed journals
  • Completed more than 970 phase I-IV clinical trials, patient outcomes studies, and comparative effectiveness analyses

DCRI Brochure cover
DCRI Brochure (2013)



The close integration of clinical faculty into the design, conduct, and interpretation of clinical trial contributes to the DCRI's unique success.

We design studies that are compatible with current clinical practice while keeping in mind the sponsor's goals, as well as increased credibility of the results.